Enzymatic Resolution of 2-Bromobutyric Acid Esters
The (R)-ester can be obtained in 98% ee on a single resolution by enzymatic hydrolysis of the racemic ester and the process has been successfully scaled up to Kilo quantities.

  
   
  Enzyme reuse is possible
Samples are available
Isolation of (S)-α-bromo acid can be achieved		  
   
 

Downstream Chemistry:
The (R)-acid, obtained from the (R)-ester, can be converted to
(S)-amino compounds in >98% ee.

  
   
     
  The (R)-bromoacid / ester also provides a potential route to useful, enantiomerically pure, downstream products.

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